Vitaran

What It Is

Polynucleotides (PNs) are DNA fragments, often from salmon sperm, that act as powerful regenerative molecules. They stimulate cellular repair, reduce inflammation, and improve skin quality through biological healing mechanisms.

Treatment Protocol

Treatment course:

• Initial series: 2-3 treatments
• Interval: 2-4 weeks
• Effect: Gradual over 4-8 weeks
• Duration: 6-9 months

MAINTENANCE:

• Every 4-6 months
• Without maintenance: Effect decreases over 3-6 months

Combinations:

• Often combined with PRP for synergistic effect
• Can be combined with microneedling
• Can be used with other skinboosters

Procedure

1. Skin cleansing
2. Numbing cream (20-30 min) - optional
3. Marking of injection points
4. Injection with fine needles into the dermis
5. Multiple small injections over the entire area
6. Massage for even distribution

Duration

30-45 minutes

Pain Level

Low to moderate. Numbing cream can be used. Many small stings. Minimal discomfort.

Downtime

Minimal downtime:

• Small red dots (hours to 1-2 days)
• Small bumps (1-3 days)
• Small bruises possible (20-30%)
• Slight swelling (1-3 days)
• Social downtime: 0-2 days
• Makeup from the next day

Healing Time

Day 0-1: Small red dots, bumps, redness

Day 2-3: Bumps flatten, redness subsides

Day 4-7: Mostly normalized

Week 2-4: Initial improvements in skin quality

Week 4-8: Gradual improvement, optimal effect

Month 3-6: Sustained effect

Side Effects

Very common:

• Small bumps (1-3 days)
• Redness (hours to 1-2 days)
• Slight swelling

Common (20-30%):

• Small bruises (5-7 days)
• Tenderness

Rare:

• Allergic reaction (especially in fish allergy)
• Granulomas (extremely rare)
• Infection (extremely rare)

Aftercare

First 24 hours:

• Do not touch your face unnecessarily
• No makeup for the first 6-12 hours
• No heat (sauna, steam room)
• No intense exercise
• No massage

Week 1:

• Gentle skin care
• SPF 50+ daily
• Avoid aggressive products (retinol, AHA, BHA)
• No facial treatments

After 1 week:

• Resume normal skin care gradually
• Still high SPF

Who Is This For

Best for:

• Dehydrated, tired skin
• Inflammatory skin conditions (rosacea, sensitive skin)
• Fine lines and texture issues
• Desire for regeneration and anti-aging
• Realistic expectations
• Willing to commit to a series and maintenance

Who Is This Not For

NOT suitable for:

• NOT for volume loss (use fillers)
• NOT for deep wrinkles (use fillers or laser)
• Pregnancy/breastfeeding
• Allergy to fish products (many PN are from salmon sperm)
• Active skin infection
• Unrealistic expectations

Important Information

REALISTIC EXPECTATIONS:

• Moderate to good effect on skin quality
• Requires series + maintenance
• Best for texture, moisture and anti-inflammatory effect
• NOT volumizing
• Gradual improvement over weeks

Documented effect:

• Anti-inflammatory (reduces skin inflammation)
• Improved skin regeneration
• Increased moisture and elasticity
• Reduction of fine lines
• Better skin texture

Contraindications

Absolute:

• Pregnancy and breastfeeding
• Allergy to fish products (if PN is from salmon sperm)
• Active skin infection
• Keloid formation (relative)

Relative:

• Autoimmune diseases (discuss with doctor)
• Blood thinning medications (increased risk of bruising)
• Previous allergic reactions

Warning Signs

Contact the clinic if you experience:

• Increasing redness and swelling after 48 hours
• Signs of infection (warmth, pus)
• Severe pain
• Allergic reaction (rash, itching, swelling)
• Harder nodules that do not go away

Individual Variations

Variation in response:

Effect:

• Good response (40-50%): Clear improvement after 4-6 weeks
• Moderate (30-40%): Improvement after 6-8 weeks
• Minimal (10-20%): Subtle effect

Duration:

• Short (4-6 months): 30%
• Average (6-9 months): 50%
• Long (9-12 months): 20%

Factors:

• Skin type and condition
• Age
• Lifestyle (smoking, stress)
• Skin care routines

Maintenance

Maintenance Schedule:

• Recommended: Every 4-6 months
• Minimum: Every 6 months
• Without maintenance: Effect decreases over 3-6 months

Tip:

• Combination with PRP often gives better and longer results
• Regular maintenance gives cumulative effect